Title:
【発明の名称】プレニル蛋白トランスフェラーゼの阻害剤
Document Type and Number:
Japanese Patent JP2002542155
Kind Code:
A
Abstract:
The present invention comprises piperazine/piperazinone-containing compounds having multicyclic ring system substituents on one of the piperazine/piperazinone nitrogens, which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.
Inventors:
Lama, William Sea, Giunia
Smith, Anthony M
Cisco, Jiyoung Tay
Smith, Anthony M
Cisco, Jiyoung Tay
Application Number:
JP2000602019A
Publication Date:
December 10, 2002
Filing Date:
March 01, 2000
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
C12N9/99; A61K31/454; A61P1/16; A61P9/10; A61P13/12; A61P27/02; A61P31/10; A61P31/12; A61P35/00; A61P35/02; A61P43/00; C07D233/54; C07D233/64; C07D401/06; C07D403/06; (IPC1-7): C07D233/64; A61K31/454; A61P1/16; A61P9/10; A61P13/12; A61P27/02; A61P31/10; A61P31/12; A61P35/00; A61P35/02; A61P43/00; C07D401/06
Attorney, Agent or Firm:
Yoshio Kawaguchi (5 outside)