Title:
【発明の名称】スフエロイド
Document Type and Number:
Japanese Patent JP2568230
Kind Code:
B2
Abstract:
A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100rpm in 900ml aqueous buffer (pH 6.5 at 37 DEG C) is between 7.5% and 25.0% (by wt) release after 1 hour, between 22.5% and 45.0% (by wt) release after 2 hours, between 40.0% and 60.0% (by wt) release after 3 hours, between 50.0% and 75.0% (by wt) release after 4 hours, between 70.0% and 92.5% (by wt) release after 6 hours, and between 80.0% and 100.0% (by wt) release after 8 hours. Preferably the water content is between 4% and 8%, especially between 4% and 7% (by wt) of the film coated spheroid formulation. The preferred 3-alkylxanthine is theophylline (anhydrous or hydrate), whilst the preferred spheronising agent is microcrystalline cellulose.
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Inventors:
SUTEYUAATO TOOMASU REZURI
SANDORA TEREEZU ANTOWANETSUTO MARUKOSUKA
JOANNU MAACHANTO
FUIRITSUPU JON NIIRU
SANDORA TEREEZU ANTOWANETSUTO MARUKOSUKA
JOANNU MAACHANTO
FUIRITSUPU JON NIIRU
Application Number:
JP30439787A
Publication Date:
December 25, 1996
Filing Date:
December 01, 1987
Export Citation:
Assignee:
EURO CELTIQUE SA
International Classes:
A61K9/28; A61K9/16; A61K9/20; A61K9/22; A61K9/50; A61K31/52; (IPC1-7): A61K31/52; A61K9/22; A61K9/28
Domestic Patent References:
| JP61152629A |
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)