Title:
INFLAMMATORY CYTOKINESIS SECRETION-SUPPRESSING AGENT
Document Type and Number:
Japanese Patent JP3826235
Kind Code:
B2
Abstract:
PURPOSE: To obtain a suppressing agent containing digitalis as an active ingredient capable of treating diseases due to production or abnormality of secretion of inflammatory cytokinesis consisting of interleukin-6, 8, monocyte chemotactic factor and granulocyte macrophage colony stimulating factor.
CONSTITUTION: This suppressing agent is obtained by blending about 0.005-0.5mg digitalis such as ouabain, digitoxin, digoxin, β-methyldigoxin, deslanoside lanatoside C or procillaridin as an active ingredient into administration unit formulation. The daily dose of the agent is normally about 0.01-1.0mg as an active ingredient. The agent is useful as a treating agent for cancer cachexia, atrial myxoma, chronic rheumatism, autoimmune diseases, psoriasis, asthma, sepsis, infectious diseases, arteriosclerosis and malignant tumor, etc.
Inventors:
Matsumori Akira
Application Number:
JP13769395A
Publication Date:
September 27, 2006
Filing Date:
June 05, 1995
Export Citation:
Assignee:
Matsumori Akira
International Classes:
A61K36/00; A61K36/18; A61K31/704; A61P13/02; A61P15/00; A61P19/10; A61P29/00; A61P31/04; A61P35/00; A61P37/04; A61P43/00; C07J19/00; (IPC1-7): A61K35/78; A61K35/78; A61K35/78; A61K35/78; A61K35/78; A61K35/78; A61K31/705; //C07J19/00
Other References:
片平潤一 他,マクロライド剤のインターロイキン-1,腫瘍壊死因子産生刺激,Chemotherapy,1991年,Vol.39,No.7,pp.678-686
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Takeshi Ohara
Kakehi Yuro
Takeshi Ohara
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