Title:
ジェランガムを含む膨張可能な投与形態
Document Type and Number:
Japanese Patent JP5154924
Kind Code:
B2
Abstract:
A dosage form in the form of a capsule, cachet, sachet, tablet, tape or laminate for oral administration of one or more active substances, the dosage form comprising a vehicle comprising
i) a gellan gum that is acylated within a degree of up to 4 per every two repeats of the glucose-rhamnose-glucose-glucoronic acid unit of the polymer, and
ii) a hydrophilic agent selected from the group consisting of electrolytes, organic acids and osmotic agents, and mixtures thereof, to improve swelling of the gellan gum,
wherein the vehicle upon addition of a predetermined amount of an aqueous medium, without the necessity of applying shear forces or other mixing forces, within a time period of 5 minutes or less swells and/or gels and the swelled composition has a viscosity of at least 10,000 mPa s (10,000 cps) as measured by a Brookfield Viscometer with a #4 LV spindle at 6 rpm and at 20-25 °C, when into a 500 ml beaker 22 - 88 g test material is accurately weighed, 500 ml tapped water is added, mix until all the material is dispersed/dissolved, and after 5 min the viscosity and the temperature are measured, wherein the Viscometer spindle is centered in the test sample container, the spindle is properly immersed to the mid-point of the shafts narrow portion; and
wherein the dosage form is capable of being converted to a semi-solid form by addition of an aqueous medium before oral administration.
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Inventors:
Bar-Shalom, Daniel
Slot, lilian
Gina Fisher
Hemingsen, Purnil, Whilap
Slot, lilian
Gina Fisher
Hemingsen, Purnil, Whilap
Application Number:
JP2007511867A
Publication Date:
February 27, 2013
Filing Date:
May 11, 2005
Export Citation:
Assignee:
EGALET A/S
International Classes:
A61K47/36; A61J7/00; A61K9/00; A61K9/06; A61K9/14; A61K9/16; A61K9/20; A61K9/50; A61K31/167; A61K31/192; A61K31/4415; A61K33/26; A61K47/02; A61K47/10; A61K47/12; A61K47/16; A61K47/18; A61K47/22; A61K47/26; A61K47/32; A61K47/34; A61K47/38; A61K47/42
Domestic Patent References:
| JP11187827A | ||||
| JP7010743A | ||||
| JP2004097114A | ||||
| JP2001508411A | ||||
| JP2002516849A |
Attorney, Agent or Firm:
Shintaro Nogawa