Title:
INFLUENZA VIRUS VACCINES AND USES THEREOF
Document Type and Number:
Japanese Patent JP2021078505
Kind Code:
A
Abstract:
To provide chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.SOLUTION: Provided herein are chimeric influenza HA polypeptides that induce a cross-protective immune response against the conserved HA stem domain of influenza viruses. The chimeric influenza HA polypeptides comprise a stable HA stem domain and a globular HA head domain that is heterologous to the stem domain.SELECTED DRAWING: Figure 2
Inventors:
ADOLFO GARCIA-SASTRE
PETER PALESE
FLORIAN KRAMMER
PETER PALESE
FLORIAN KRAMMER
Application Number:
JP2021010188A
Publication Date:
May 27, 2021
Filing Date:
January 26, 2021
Export Citation:
Assignee:
ICAHN SCHOOL MED MOUNT SINAI
International Classes:
C12N15/44; A61K39/00; A61K39/12; A61K39/135; A61K39/17; A61K39/235; A61P31/16; C07K14/11; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01
Attorney, Agent or Firm:
Toru Ishikawa