Title:
動物モデルにおけるミエロペルオキシダーゼ酸化活性のＰＩＣ１による阻害
Document Type and Number:
Japanese Patent JP7031011
Kind Code:
B2
Abstract:
A method of treating systemic lupus erythematosus in a subject is provided in which a therapeutically effective amount of PIC1 is administered to the subject. A method of treating transfusion-related acute lung injury is also provided where a therapeutically effective amount of PIC1 is administered to the subject. PIC1 can modulate immune complex activation of the complement system and NET formation in the subject. PIC1 can also inhibit myeloperoxidase (MPO) activity in the subject.
Inventors:
Krishna Neil Kay.
Kenji Kunion
Kenji Kunion
Application Number:
JP2020557135A
Publication Date:
March 07, 2022
Filing Date:
January 08, 2019
Export Citation:
Assignee:
Realta Holdings Limited Liability Company
International Classes:
A61K38/10; A61K47/60; A61P11/00; A61P29/00; A61P37/06
Domestic Patent References:
| JP2013533273A |
Foreign References:
| WO2016210370A1 |
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto