Title:
INHIBITION OF SECRETION FROM NON-NEURONAL CELL
Document Type and Number:
Japanese Patent JP2011184459
Kind Code:
A
Abstract:
To provide a treating means of a disease by inhibition of a cellular secretory process.
A medicine contains at least a first, a second and a third domains and inhibits secretion from a non-neuronal cell, wherein the first domain contains a fragment which cuts at least one protein essential for a light chain or exocytosis of a clostridium bacillus nerve toxin, the second domain contains a translocation domain which translocates the first domain to the non-neuronal cell, and the third domain specifically combines the medicine with a combining part on the non-neuronal cell.
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Inventors:
FOSTER KEITH ALAN
CHADDOCK JOHN ANDREW
PURKISS JOHN ROBERT
QUINN CONRAD PADRAIG
CHADDOCK JOHN ANDREW
PURKISS JOHN ROBERT
QUINN CONRAD PADRAIG
Application Number:
JP2011132301A
Publication Date:
September 22, 2011
Filing Date:
June 14, 2011
Export Citation:
Assignee:
SYNTAXIN LTD
International Classes:
A61K38/00; A61K45/00; A61K36/06; A61K39/395; A61K47/48; A61K48/00; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P5/00; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P27/14; A61P27/16; A61P29/00; A61P37/02; A61P37/08
Domestic Patent References:
| JPH09500867A | 1997-01-28 | |||
| JPH11504006A | 1999-04-06 | |||
| JP2002514659A | 2002-05-21 |
Foreign References:
| WO1998007864A1 | 1998-02-26 | |||
| WO1999058571A2 | 1999-11-18 |
Other References:
JPN6011047651; ＡＭ．Ｊ．ＰＨＹＳＩＯＬ．ＲＥＮＡＬ．ＰＨＹＳＩＯＬ． ＶＯＬ．２７３, 1997, Ｐ．Ｆ１０５４-１０５７
JPN6011047655; Ｊ．ＢＩＯＬ．ＣＨＥＭ． ＶＯＬ．２７１， ＮＯ．１３, 1996, Ｐ．７３２４-７３２９
JPN6011047662; Ｊ．ＢＩＯＬ．ＣＨＥＭ． ＶＯＬ．２７０， ＮＯ．３１, 1995, Ｐ．１８２１６-１８２１８
JPN6011047658; ＥＮＤＯＣＲＩＮＯＬ． ＶＯＬ．１３８， ＮＯ．１２, 1997, Ｐ．５５１８-５５２６
JPN6011047660; 医学のあゆみ ＶＯＬ．１６９， ＮＯ．８, 1994, Ｐ．８５０-８５５
JPN6011047655; Ｊ．ＢＩＯＬ．ＣＨＥＭ． ＶＯＬ．２７１， ＮＯ．１３, 1996, Ｐ．７３２４-７３２９
JPN6011047662; Ｊ．ＢＩＯＬ．ＣＨＥＭ． ＶＯＬ．２７０， ＮＯ．３１, 1995, Ｐ．１８２１６-１８２１８
JPN6011047658; ＥＮＤＯＣＲＩＮＯＬ． ＶＯＬ．１３８， ＮＯ．１２, 1997, Ｐ．５５１８-５５２６
JPN6011047660; 医学のあゆみ ＶＯＬ．１６９， ＮＯ．８, 1994, Ｐ．８５０-８５５
Attorney, Agent or Firm:
Takuya Shindo