Title:
タウ-タウ会合の阻害
Document Type and Number:
Japanese Patent JP3612078
Kind Code:
B2
Abstract:
The present invention relates to novel methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association and pathological neurofilament aggregation. The methods of the present invention are particularly useful in screening substances for the prophylaxis and treatment of Alzheimer's disease, motor neuron disease, Lewy body disease, Pick's disease and progressive supranuclear palsy. In addition, substances capable of selectively inhibiting pathological aggregates while preserving normal cytoskeletal function are described.
Inventors:
Wishik, Claude Michel
Edwards, Patricia Carroll
Charles Robert, Harrington
Ross, martin
Krug, Aaron
Edwards, Patricia Carroll
Charles Robert, Harrington
Ross, martin
Krug, Aaron
Application Number:
JP52891696A
Publication Date:
January 19, 2005
Filing Date:
March 25, 1996
Export Citation:
Assignee:
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
International Classes:
G01N33/53; A61K31/54; A61K31/5415; A61P25/28; C07D279/20; C07K14/47; G01N33/15; G01N33/50; G01N33/531; G01N33/543; G01N33/566; G01N33/68; (IPC1-7): G01N33/15; A61K31/54; C07D279/20; G01N33/53; G01N33/531; G01N33/543; G01N33/566
Domestic Patent References:
| JP7507044A | ||||
| JP8502898A | ||||
| JP6239899A |
Foreign References:
| WO1993003369A1 | ||||
| WO1995017429A1 | ||||
| WO1996004915A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda