INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30

Japanese Patent JP2023123613

A

To provide chemical entities useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), and pharmaceutical compositions comprising the chemical entities.SOLUTION: Provided herein is a chemical entity which is a compound represented by the following formula [where R is hydrogen, OH, CN, an alkyl group, an alkoxy group or the like; n is 0-2; R1 is a heterocyclic group; R2 is C(X) n, S(O)2, N(X), a heteroatom linker, N(X)S(O)2, N(X)S(O)2N(X) or the like, with X being hydrogen, an alkyl group, or a heteroalkyl group; R3 is hydrogen, halogen, an alkyl group, a heteroalkyl group, a haloalkyl group, an alkoxy group or the like; R4 is an alkyl group, a heteroalkyl group, a haloalkyl group, an alkoxy group or the like; m is 0, 1, or 2].SELECTED DRAWING: None

JUSTIN CARAVELLA
HAN BINGSONG
LIU CUIXIAN
STEPHANOS IOANNIDIS
ALEXANDRE JOSEPH BUCKMELTER
DAVID JAMES RICHARD
MATTHEW W MARTIN
STEVEN MISCHKE
SCOT MENTE

JP2023100583A

September 05, 2023

June 20, 2023

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FORMA THERAPEUTICS INC

C07D417/04; A61K31/275; A61K31/415; A61K31/42; A61K31/422; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/4453; A61K31/454; A61K31/495; A61K31/5375; A61P43/00; C07C261/04; C07D213/75; C07D231/14; C07D261/14; C07D261/18; C07D263/48; C07D277/32; C07D277/44; C07D277/82; C07D295/155; C07D295/185; C07D413/10; C07D413/14; C07D417/06; C07D417/12

Norito Yamao
Sei Morimoto
Nobuhiko Akiyama

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