Title:
ＫＥＡＰ１－Ｎｒｆ２タンパク質－タンパク質相互作用の阻害剤
Document Type and Number:
Japanese Patent JP7212763
Kind Code:
B2
Abstract:
Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Inventors:
Barvey Jay Kent
Chai Wen-in
Hurst Gavin Sea
Clutter Kevin Di
Kummer David A
McClure Kelly Jaye
Nishimura Rachel Tea
Sea Amy Wai
Benable Jennifer Di
Benkatesan Hariharan
Wei Jang Mei
Chai Wen-in
Hurst Gavin Sea
Clutter Kevin Di
Kummer David A
McClure Kelly Jaye
Nishimura Rachel Tea
Sea Amy Wai
Benable Jennifer Di
Benkatesan Hariharan
Wei Jang Mei
Application Number:
JP2021509891A
Publication Date:
January 25, 2023
Filing Date:
August 19, 2019
Export Citation:
Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D419/10; A61K31/4192; A61K31/437; A61K31/519; A61K31/554; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P27/02; A61P31/04; A61P43/00; C07D471/04; C07D513/04; C07D513/10; C07D513/14; C07D515/20; C07D519/00
Domestic Patent References:
| JP2017503786A | ||||
| JP2018517731A |
Foreign References:
| WO2018109647A1 |
Other References:
Thomas G. Davies, et.al.,Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2),J. Med. Chem.,2016年,Vol.59,p.3991-4006
Attorney, Agent or Firm:
Kiminobu Kato
Takafumi Oshima
Takafumi Oshima
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