PURPOSE: To obtain the subject chemically stable inhibitor, containing a glycoside of an aglycone having a specific skeleton as an active ingredient, mild in actions, excellent in persistence of the actions and useful as an antiinflammatory, an antiallergic and antiulcer agents.
CONSTITUTION: This inhibitor contains a glycoside of an aglycone having a flavan-3-ol skeleton as an active ingredient. Furthermore, the glycoside preferably contains any one of the group consisting of O-α-glycosides, O-β-glycosides and C-glycosides and further a glycoside comprising a sugar component which is glucose and an aglycone component that is (-)-catechin (e.g. 3,3'-4',5,7- pentahydroxyflavan represented by formula I), (+)-catechin (e.g. 3,3',4,5,7- pentahydroxyflavan represented by formula II), (-)-epicatechin, (+)-epicatechin, (-)-(epi)gallocatechin or a gallate derivative thereof. For example, the aglycone component is preferably obtained by extraction or separation thereof from a plant, especially a leaf of green tea.
| WO/1993/020078 | PHARMACEUTICALLY ACTIVE BICYCLIC-HETEROCYCLIC AMINES |
| WO/2021/056270 | SENOLYTIC PRODRUGS AND METHODS OF USE THEREOF |
KITAO SATORU
ICHIKAWA ATSUSHI
KIKKOMAN CORP