Title:
ヒストンデアセチラーゼの阻害剤
Document Type and Number:
Japanese Patent JP5727649
Kind Code:
B2
Abstract:
This invention relates to five specific N-hydroxybenzamide compounds for the inhibition of histone deacetylase: N-hydroxy-4-(5-(p-tolyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)benzamide; N-hydroxy-4-(5-(3-methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)benzamide; N-hydroxy-4-(5-(4-(trifluoromethyl)pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)benzamide; 4-(benzo[b]thieno[2,3-f][1,4]oxazepin-10-yl)-N-hydroxybenzamide; and 4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-hydroxybenzamide.
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Inventors:
Desire, Robert
Riet, Silvana
Volume, Patrick
Chantilly, Eve, Andre
John Mancozo
Tessier, Pierre
Shapiro, Gideon
Chessworth, Richard
Smil, David
Riet, Silvana
Volume, Patrick
Chantilly, Eve, Andre
John Mancozo
Tessier, Pierre
Shapiro, Gideon
Chessworth, Richard
Smil, David
Application Number:
JP2014111281A
Publication Date:
June 03, 2015
Filing Date:
May 29, 2014
Export Citation:
Assignee:
Methyl Gene Incorporated
Form Pharmaceuticals, Inc.
Form Pharmaceuticals, Inc.
International Classes:
C07D498/04; A61K31/4985; A61K31/55; A61K31/553; A61P25/14; A61P25/28; A61P43/00; C07D223/22; C07D471/08; C12N9/99
Domestic Patent References:
| JP2005503341A | ||||
| JP2005526763A |
Foreign References:
| WO2006097449A1 | ||||
| WO2006088949A1 |
Other References:
MILLER T A,EXPERT OPINION ON THERAPEUTIC PATENTS,英国,ASHLEY PUBLICATIONS,2004年 1月 1日,V14 N6,P791-804
Attorney, Agent or Firm:
Asamura patent office