Title:
C-JUNN末端キナーゼ(JNK)および他のタンパク質キナーゼのインヒビター
Document Type and Number:
Japanese Patent JP4377583
Kind Code:
B2
Abstract:
The present invention provides compounds of formula I: wherein G is a small group selected from hydrogen or C1-3 alkyl, Q is pyridine or pyrimidine, and R1-R3 are as defined in the specification. These compounds are selective JNK inhibitors showing good activity against the three isoforms of JNK (JNK1, JNK2 and JNK3) and relatively low activity against p38 kinase. The compounds are therefore useful for treating JNK-mediated diseases, especially neurodegenerative diseases in which all three JNK isoforms are implicated.
Inventors:
Lead bore, mark
Salituro, Francesco
Moon, Young-Tune
Salituro, Francesco
Moon, Young-Tune
Application Number:
JP2002547922A
Publication Date:
December 02, 2009
Filing Date:
December 05, 2001
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07D239/38; C07D403/04; A61K31/415; A61K31/505; A61K31/506; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/00; A61P7/00; A61P7/02; A61P7/06; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/08; A61P43/00; C07C311/47; C07D231/12; C07D401/04; C07D401/14; C07D403/14
Foreign References:
| WO2000031063A1 | ||||
| WO1998052940A1 | ||||
| WO1998052941A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita