Title:
老化細胞由来DNA合成阻害因子
Document Type and Number:
Japanese Patent JP3822232
Kind Code:
B2
Abstract:
An expression vector cDNA library derived from senescent cells has been used to isolate cDNA clones that encode inhibitors of DNA synthesis. Such inhibitors play a role in cellular senescence, aging and neoplasia. Antisense nucleic acids reduce the inhibition of DNA synthesis. The invention concerns such molecules, their inhibitors, antagonists and derivatives. The invention also concerns diagnostic, therapeutic and in vitro uses for all such agents.
Inventors:
Smith, James Earl
Noda Asao
Adami, Guy
Noda Asao
Adami, Guy
Application Number:
JP50820395A
Publication Date:
September 13, 2006
Filing Date:
August 26, 1994
Export Citation:
Assignee:
Baylor College of Medicine
International Classes:
C12N15/09; G01N33/53; A61K38/00; A61K39/395; A61K48/00; A61P35/00; C07H21/00; C07H21/04; C07K14/47; C07K16/18; C07K19/00; C12N5/10; C12N9/10; C12N15/113; C12P21/02; C12P21/08; C12R1/91
Foreign References:
| WO1993012251A1 |
Other References:
Exp Cell Res 211 p.90-98 (1994)
Cell 75 p.817-825 (1993)
Cell 75 p.817-825 (1993)
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Shoji Nakajima
Kyousei Tamura
Shoji Nakajima