Title:
１７β−ＨＳＤ１、１７β−ＨＳＤ３、および１７β−ＨＳＤ１０の阻害剤
Document Type and Number:
Japanese Patent JP6727184
Kind Code:
B2
Abstract:
The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17β HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17β HSD1 and 17β HSD3 that have a spiro-morpholine substituent at C20.
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Inventors:
Donald Polier
Rene Marte
Junie Roy
Rene Marte
Junie Roy
Application Number:
JP2017253315A
Publication Date:
July 22, 2020
Filing Date:
December 28, 2017
Export Citation:
Assignee:
UNIVERSITE LAVAL
International Classes:
A61K31/565; A61K31/567; A61K31/58; A61P35/00; A61P43/00
Domestic Patent References:
| JP1132523A | ||||
| JP2010503718A | ||||
| JP2008545678A | ||||
| JP2007510697A |
Foreign References:
| WO2008065100A1 |
Other References:
Bioorganic & Medicinal Chemistry,2008年,16,1849-1860
Biochemical Journal,2009年,424,357-366
Molecules,2010年,(15),1590-1631
Journal of Medicinal Chemistry,2002年,45(3),640-653
ACS Medicinal Chemistry Letters,2011年 7月17日,2,678-681
Medicinal Chemistry,2011年,7(2),80-91
Journal of Steroid Biochemistry,1990年,36(6),617-629
Biochemical Journal,2009年,424,357-366
Molecules,2010年,(15),1590-1631
Journal of Medicinal Chemistry,2002年,45(3),640-653
ACS Medicinal Chemistry Letters,2011年 7月17日,2,678-681
Medicinal Chemistry,2011年,7(2),80-91
Journal of Steroid Biochemistry,1990年,36(6),617-629
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Shinya Mitsuhiro