ＳＡＲＭ１ＮＡＤアーゼ活性の阻害剤およびその使用

Title:

ＳＡＲＭ１ＮＡＤアーゼ活性の阻害剤およびその使用

Document Type and Number:

Japanese Patent JP7044789

Kind Code:

B2

Abstract:

The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

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Inventors:

Milbrandt, Jeffrey
Essman, Kou
Hiroshi Sasaki
Di Antonio, Aaron
Mao, Shanlong
Debraj, Rajesh
Klaus, Raul Eduardo
Hughes, Robert Owen

Application Number:

JP2019537755A

Publication Date:

March 30, 2022

Filing Date:

September 22, 2017

Export Citation:

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Assignee:

Washington University

International Classes:

A61K31/4439; A61K31/385; A61K31/7084; A61P3/00; A61P3/02; A61P7/00; A61P7/06; A61P9/10; A61P21/02; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P39/02; A61P43/00; C07K14/47; C07K17/00; C12N1/21; C12N5/10; C12N9/26; C12N15/56; C12N15/63; C12Q1/02; C12Q1/34

Other References:

SCIENCE,2015年,24; 348 (6233),p.453-457
PLOS ONE,2013年,Volume 8, Issue 7, e70487
BRAIN,2016年,6: 139,p. 1094-1105
Neuron,2106年,89, 3,p. 449-460
The Journal of Cell Biology,2005年,Vol. 170, No. 3,p. 349-355

Attorney, Agent or Firm:

Hiroshi Kobayashi
Norio Omori
Yasuhito Suzuki

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