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Title:
ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ
Document Type and Number:
Japanese Patent JP2010513326
Kind Code:
A
Abstract:
The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Inventors:
Dejielle, robert
Ajamian, Alan
Application Number:
JP2009541704A
Publication Date:
April 30, 2010
Filing Date:
December 19, 2007
Export Citation:
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Assignee:
Mesilegene Incorporated
International Classes:
C07C259/10; A61K31/16; A61K31/17; A61K31/18; A61K31/341; A61K31/343; A61K31/36; A61K31/381; A61K31/404; A61K31/433; A61K31/4402; A61K31/47; A61P31/10; A61P35/00; A61P43/00; C07C275/38; C07C311/21; C07C311/29; C07C311/44; C07C317/24; C07C321/28; C07D209/08; C07D213/71; C07D215/36; C07D285/135; C07D307/16; C07D307/54; C07D307/91; C07D317/60; C07D333/34; C07D333/38; C07D333/62; C12N15/113
Foreign References:
WO2007072179A22007-06-28
WO2001038322A12001-05-31
WO2006017214A22006-02-16
EP1541549A12005-06-15
US3479396A1969-11-18
Other References:
JPN6013013523; Chhaya, P. N.; Nimbalkar, M. M.; Hosangadi, B. D.: 'Acid-catalyzed reactions of ortho-substituted benzohydroxamic acids in polyphosphoric acid (PPA)' Journal of Organic Chemistry 51(23), 1986, 4458-60
JPN6013013524; Bouchain, Giliane; Delorme, Daniel: 'Novel hydroxamate and anilide derivatives as potent histone deacetylase inhibitors: Synthesis and an' Current Medicinal Chemistry 10(22), 2003, 2359-2372
JPN6013013527; Moradei, Oscar; Maroun, Christiane R.; Paquin, Isabelle; Vaisburg, Arkadii: 'Histone deacetylase inhibitors: Latest developments, trends and prospects' Current Medicinal Chemistry: Anti-Cancer Agents 5(5), 2005, 529-560
JPN6013013528; Guillaumel, Jean; Demerseman, Pierre; Clavel, Jean Marc; Royer, Rene: 'Synthesis of 3-chloroindolinones from variously substituted beta-nitrostyrenes' Journal of Heterocyclic Chemistry 17(7), 1980, 1531-6
JPN6013013529; Eckstein, Zygmunt: 'Synthesis of 6-methoxybenzoxazolone' Przemysl Chemiczny 41(No. 2), 1962, 66-8
JPN6013013531; Hua, Duy H. et al.: 'Antiprotozoal activities of symmetrical bishydroxamic acids' Bioorganic and Medicinal Chemistry 11(20), 2003, 4357-4361
JPN6013013532; Ohemeng, Kwasi A. et al.: 'Novel bishydroxamic acids as 5-lipoxygenase inhibitors' Bioorganic and Medicinal Chemistry 2(3), 1994, 187-93
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Yuko Nagase
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Youichi Inoue
Mari Yuge