Title:
INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS- AND/OR LYMPHANGIOGENESIS-RELATED DISEASES
Document Type and Number:
Japanese Patent JP2023011613
Kind Code:
A
Abstract:
To provide compounds that inhibit SOX18 protein activity.SOLUTION: There is provided a compound of formula (I), or a pharmaceutically acceptable salt, solvate or prodrug thereof (wherein, R1 is OH or OR6; R6 is C1-C4 alkyl; R2 is H, COOR7 or C(O)NR8R9; R7, R8 and R9 are independently H or C1-C4 alkyl; R3 is L-A; L is C2-C8 alkyl, C2 -C8 alkenyl and C2-C8 alkoxyalkyl; A is substituted/unsubstituted phenyl or substituted/unsubstituted naphthyl; R4 is H, OR10, halo or C1-C4 alkyl; R10 is H or C1-C4 alkyl; R5 is H, OR11, halogen or C1-C4 alkyl; and R11 is H or C1-C4 alkyl.).SELECTED DRAWING: None
Inventors:
Francois Matthias
Zoig Johannes
Auvermann Jörn
Mamidiara Suleman Kumar
Salim Angela Agusluyarthi
Fontaine Frank Roger
Cooper Matthew Alistair
capon robert john
Robertson Avril Alexis Barbara
Zoig Johannes
Auvermann Jörn
Mamidiara Suleman Kumar
Salim Angela Agusluyarthi
Fontaine Frank Roger
Cooper Matthew Alistair
capon robert john
Robertson Avril Alexis Barbara
Application Number:
JP2022162614A
Publication Date:
January 24, 2023
Filing Date:
October 07, 2022
Export Citation:
Assignee:
The University of Queensland
International Classes:
C07C65/105; A61K31/047; A61K31/09; A61K31/166; A61K31/192; A61P35/00; A61P43/00; C07C39/15; C07C43/215; C07C65/19; C07C65/21; C07C65/26; C07C65/28; C07C235/60
Attorney, Agent or Firm:
Sykes Patent Attorney Corporation
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