INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF LEUCYL-tRNA SYNTHETASES

Japanese Patent JP2016036344

A

PROBLEM TO BE SOLVED: To provide compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases (AARS), polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.SOLUTION: A composition comprises an AARS protein fragment of at least 70 amino acids, possessing non-canonical biological activities, such as extracellular signaling activities, and/or other characteristics of therapeutic and diagnostic relevance. The AARS protein fragment has a solubility of at least about 5 mg/mL. The composition has a purity of at least about 95% on a protein basis and less than about 10 EU/mg protein endotoxin. The composition is substantially serum free.SELECTED DRAWING: None

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LESLLE ANN GREENE
KYLE P CHIANG
HONG FEI
ALAIN P VASSEROT
LO WING-SZE
JEFFRY D WATKINS
CHERYL L QUINN
JOHN D MENDLEIN

JP2015188044A

March 22, 2016

September 25, 2015

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ATYR PHARMA INC
PANGU BIOPHARMA LTD

C12N9/00; A61K38/00; A61K39/395; A61K47/34; A61K47/48; A61P3/00; A61P3/10; A61P7/00; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P43/00; C07K14/00; C07K16/40; C07K19/00; C12M3/00; C12N5/07; C12N15/09; C12N15/113; C12P21/06; C12Q1/00; C12Q1/02; G01N33/15; G01N33/50

Hidesaku Yamamoto
Natsuki Morishita

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