Title:
インスリン様作用を有するイノシトールグリカン
Document Type and Number:
Japanese Patent JP4299378
Kind Code:
B2
Abstract:
Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).
Inventors:
Vendelene Frick
Guilunter Miuler
Guilunter Miuler
Application Number:
JP32550897A
Publication Date:
July 22, 2009
Filing Date:
November 27, 1997
Export Citation:
Assignee:
Hoechst Gesellschaft Mito Beschlenktel Haftung
International Classes:
C07H11/04; A61K31/70; C07H15/207; A61K31/7024; A61K31/7028; A61K31/7034; A61K31/715; A61K31/716; A61K38/28; A61P3/08; A61P3/10; A61P5/00; A61P5/48; C07H3/04; C07H3/06; C07H15/203; C08B37/00
Domestic Patent References:
| JP6293790A |
Foreign References:
| WO1996014075A1 |
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura