Title:
INTEGRIN RECEPTOR ANTAGONIST
Document Type and Number:
Japanese Patent JP2004300158
Kind Code:
A
Abstract:
To provide an integrin receptor antagonist.
The compounds and derivatives thereof, synthesis threof and their use as integrin receptor antagonists are provided. More particularly, the compounds are antagonists of the integrin receptors αvβ3, αvβ5 and/or αvβ6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.
Inventors:
DUGGAN MARK E
MEISSNER ROBERT S
HUTCHINSON JOHN H
HALCZENKO WASYL
ASKEW BEN C
COLEMAN PAUL J
PATANE MICHAEL A
WANG JIABING
PERKINS JAMES J
MEISSNER ROBERT S
HUTCHINSON JOHN H
HALCZENKO WASYL
ASKEW BEN C
COLEMAN PAUL J
PATANE MICHAEL A
WANG JIABING
PERKINS JAMES J
Application Number:
JP2004185935A
Publication Date:
October 28, 2004
Filing Date:
June 24, 2004
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/415; A61K31/4375; A61K31/44; A61K31/4427; A61K31/4439; A61K31/444; A61K31/4709; A61K31/538; A61K31/5383; A61K31/66; A61K31/663; A61K45/00; A61K45/06; A61P3/14; A61P9/00; A61P9/10; A61P17/02; C07D401/06; A61P19/08; A61P19/10; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D401/14; C07D471/04; C07D519/00; C07D; (IPC1-7): C07D401/14; A61K31/4375; A61K31/4439; A61K31/538; A61K31/5383; A61K31/663; A61K45/00; A61P9/00; A61P9/10; A61P19/08; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D471/04; C07D519/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
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