Title:
経肺投与用インターフェロン-γ凍結乾燥組成物及びその吸入システム
Document Type and Number:
Japanese Patent JP2006509825
Kind Code:
A
Abstract:
The present invention provides a freeze-dried interferon-gamma composition for transpulmonary administration which can maintain IFN-gamma stably, and can be prepared into fine particles in a vessel at the time of use. A freeze-dried interferon-gamma composition for transpulmonary administration of the present invention has the following properties (i) to (iv): (i) containing at least one hydrophobic stabilizer selected from the group consisting of hydrophobic amino acids, dipeptides of hydrophobic amino acids, tripeptides of hydrophobic amino acids and derivatives of hydrophobic amino acids and salts thereof; at least one hydrophilic stabilizer selected from the group consisting of hydrophilic amino acids, dipeptides of hydrophilic amino acids, tripeptides of hydrophilic amino acids, derivatives of hydrophilic amino acids and salts thereof; and interferon-gamma(ii) a non-powder cake-like form; (iii) a disintegration index of 0.015 or more; and (iv) becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec.
Inventors:
Chiyomasa Yamashita
Shigeru Ibaraki
Shigeru Ibaraki
Application Number:
JP2004560629A
Publication Date:
March 23, 2006
Filing Date:
December 12, 2003
Export Citation:
Assignee:
Otsuka Pharmaceutical Co., Ltd.
International Classes:
A61K38/21; A61K9/00; A61K9/19; A61K9/72; A61K47/18; A61K47/42; A61M15/00
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Junya Tanaka
Kakehi Yuro
Junya Tanaka