To provide humanized monoclonal antibodies which recognize human IL-10 and modulate its activity with regard to autoimmune disorders.
Compositions and methods disclosed herein relate generally to interleukin-10 (IL-10) specific antibodies and uses thereof. More specifically, the invention relates to the composition of humanized IL-10 specific antibody in the modulation of IL-10 activity (particularly in autoimmune disorders and pathogen-induced immunopathology), and using methods for such antibodies. The humanized monoclonal antibodies recognize human IL-10, particularly to autoimmune disorders, and modulate its activity. The humanized antibodies provide an alternative therapy choice without the toxicity and non-specificity associated with current treatments.
Takaaki Yasumura
Natsuki Morishita
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