Title:
非メバロン酸イソプレノイド経路の中間体及び酵素
Document Type and Number:
Japanese Patent JP4068971
Kind Code:
B2
Abstract:
The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.
Inventors:
Bach, Adelbert
Rodich, Felix
Adam and Petra
Amslinger, Sabine
Eisenreich, Wolfgang
Hecht, Stefan
Rodich, Felix
Adam and Petra
Amslinger, Sabine
Eisenreich, Wolfgang
Hecht, Stefan
Application Number:
JP2002581475A
Publication Date:
March 26, 2008
Filing Date:
April 10, 2002
Export Citation:
Assignee:
Bacher, Adelbad
Rodich, Felix
Rodich, Felix
International Classes:
C07F9/113; G01N33/50; A61K31/663; A61P31/04; A61P37/02; A61P37/04; A61P43/00; C07C33/025; C07C33/03; C07C33/035; C07C47/263; C07F9/09; C07H19/10; C07K16/44; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12N9/16; C12N9/88; C12N9/99; C12N15/09; C12N15/52; C12N15/55; C12P9/00; C12Q1/02; G01N33/15; G01N33/569; A01H5/00; A01K67/027; C07B61/00
Foreign References:
| WO2000072022A1 | ||||
| WO1999058649A1 | ||||
| US4950797 | ||||
| US4257960 | ||||
| EP0309906A1 | ||||
| WO2000017233A1 | ||||
| WO2001085950A1 | ||||
| WO2002026852A1 |
Other References:
FEMS Microbiol. Lett.,1992年,vol. 94,175-180
GenBank/EMBL Accession BAB09833,2000年
J. Bacteriol.,2000年,vol. 183,5841-5848
J. Immunol.,2001年 3月,vol. 166,3655-3658
FEBS Lett.,2001年 1月,vol. 488,170-173
PubMed ID 11274098,2001年 3月29日,J. Bacteriol. 183 (2001) 2411-2416
J. Org. Chem.,1987年,vol. 51,4768-4779
FEBS Lett.,2001年11月,vol. 509,317-322
J. Bacteriol.,2001年 4月,vol. 183,2411-2416
FEBS Lett.,2000年,vol. 473,328-332
J. Bacteriol.,1993年,vol. 175,1203-1205
J. Biol. Chem.,1999年,vol. 274,32079-32084
J. Bacteriol.,2001年12月,vol. 183,7403-7407
FEBS Lett.,2001年 5月,vol. 499,37-40
Proc. Natl. Acad. Sci. USA,2000年,vol. 97,6451-6456
Proc. Natl. Acad. Sci. USA,2000年,vol. 97,1062-1067
Biochem. Soc. Transact.,2000年,vol. 28,785-789
Z. Naturforsch. C,2000年,vol. 55,305-313
GenBank/EMBL Accession BAB09833,2000年
J. Bacteriol.,2000年,vol. 183,5841-5848
J. Immunol.,2001年 3月,vol. 166,3655-3658
FEBS Lett.,2001年 1月,vol. 488,170-173
PubMed ID 11274098,2001年 3月29日,J. Bacteriol. 183 (2001) 2411-2416
J. Org. Chem.,1987年,vol. 51,4768-4779
FEBS Lett.,2001年11月,vol. 509,317-322
J. Bacteriol.,2001年 4月,vol. 183,2411-2416
FEBS Lett.,2000年,vol. 473,328-332
J. Bacteriol.,1993年,vol. 175,1203-1205
J. Biol. Chem.,1999年,vol. 274,32079-32084
J. Bacteriol.,2001年12月,vol. 183,7403-7407
FEBS Lett.,2001年 5月,vol. 499,37-40
Proc. Natl. Acad. Sci. USA,2000年,vol. 97,6451-6456
Proc. Natl. Acad. Sci. USA,2000年,vol. 97,1062-1067
Biochem. Soc. Transact.,2000年,vol. 28,785-789
Z. Naturforsch. C,2000年,vol. 55,305-313
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda