Title:
INTESTINAL ORGANOID AND METHOD FOR MANUFACTURING THE SAME
Document Type and Number:
Japanese Patent JP2023171886
Kind Code:
A
Abstract:
To provide an intestinal organoid equipped with the same function as an intestine, and a method for manufacturing the organoid.SOLUTION: An intestinal organoid of the present invention is derived from an embryonic stem cell and/or an artificial pluripotent stem cell, has a structure including a cavity, and a length in a long axis direction is 5 mm or more. A method for manufacturing an intestinal organoid of the present invention includes: a process 1 of inoculating a cell selected from an embryonic stem cell and an artificial pluripotent stem cell onto a substrate and a cell culture substrate including a cell adhesion region and a cell non-adhesion region surrounding the cell adhesion region which are formed on the surface of the substrate; and a process 2 of culturing a cell inoculated in the process 1. The process 2 includes differentiating a part of a cell into an entodermal cell and differentiating a part of a cell into an ectodermal cell.SELECTED DRAWING: Figure 1D
Inventors:
OKAZAKI TAKUYA
UMEZAWA AKIHIRO
AKUTSU HIDENORI
UCHIDA TAKESHI
UMEZAWA AKIHIRO
AKUTSU HIDENORI
UCHIDA TAKESHI
Application Number:
JP2023171348A
Publication Date:
December 05, 2023
Filing Date:
October 02, 2023
Export Citation:
Assignee:
DAINIPPON PRINTING CO LTD
NAT CENTER FOR CHILD HEALTH & DEVELOPMENT
NAT CENTER FOR CHILD HEALTH & DEVELOPMENT
International Classes:
C12N5/071; C12Q1/02
Attorney, Agent or Firm:
Patent Attorney Corporation Hiraki International Patent Office