Title:
骨誘導タンパク質及びペプチドの細胞内送達
Document Type and Number:
Japanese Patent JP2007505621
Kind Code:
A
Abstract:
The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.
Inventors:
Titus, Frances
Marks, Jeffrey
Dora Pho, Susan
Borden, Scott
Yun, San Wook
Marks, Jeffrey
Dora Pho, Susan
Borden, Scott
Yun, San Wook
Application Number:
JP2006526862A
Publication Date:
March 15, 2007
Filing Date:
April 13, 2004
Export Citation:
Assignee:
Medtronic Sofamore Duneck
International Classes:
C12N15/09; A61K35/28; A61K35/32; A61K38/00; A61P19/00; A61P19/02; A61P19/04; A61P19/08; A61P41/00; A61P43/00; C07H21/04; C07K5/00; C07K14/16; C07K14/51; C07K19/00; C12N15/861; C12P21/02; A61K48/00
Foreign References:
| WO2002034116A2 | 2002-05-02 | |||
| WO2002096952A2 | 2002-12-05 | |||
| WO2003012111A2 | 2003-02-13 | |||
| WO2003042368A2 | 2003-05-22 | |||
| WO2000066178A1 | 2000-11-09 | |||
| WO1999006563A1 | 1999-02-11 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura