Title:
SUSTAINED RELEASE SUSPENSION PHARMACEUTICAL HAVING STABLE RELEASE PROPERTY
Document Type and Number:
Japanese Patent JP3207495
Kind Code:
B2
Abstract:
PURPOSE: To obtain a sustained release aqueous suspension pharmaceutical having stable release properties of a medicine for a long period just after its production.
CONSTITUTION: The release properties of a medicine are stabilized by supporting an amino acid, preferably glutamic acid, glycine, alanine, lysine, histidine or a salt thereof at preferably 0.05-2wt./vol.%, especially 0.1-1wt./vol.% concentration to a sustained release suspension pharmaceutical prepared by suspending (A) the first ionic medicine such as codeine, dihydrocodeine, dextromethorphan, phenylpropanolamine, methylephedrine or hydrocodone on (B) an ion exchange resin, then coating the resultant complex A-B with an insoluble polymer, supporting (C) the second ionic medicine having charge of the same kind as that of the ingredient (A), e.g. pheniramine on the same ion exchange resin as the ingredient (B), suspending the prepared C-B complex particles in an aqueous medium and regulating the pH of the suspension pharmaceutical to preferably 3-7. Thereby, the early chemical equilibrium is reached among both the medicines (A) and (C) and the ion exchange resin (B).
Inventors:
Youko Mitani
Umemoto Mitsuo
Seiji Higashi
Umemoto Mitsuo
Seiji Higashi
Application Number:
JP8108692A
Publication Date:
September 10, 2001
Filing Date:
April 02, 1992
Export Citation:
Assignee:
Rohto Pharmaceutical Co., Ltd.
International Classes:
A61K9/10; A61K47/48; (IPC1-7): A61K9/10; A61K47/48
Domestic Patent References:
| JP5279246A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
Previous Patent: An autonomous fluid pump which conveys fluid to a living body
Next Patent: BEARING HOLDING STRUCTURE OF SUN VISOR FOR VEHICLE
Next Patent: BEARING HOLDING STRUCTURE OF SUN VISOR FOR VEHICLE