Title:
植物性エストロゲンのイソフラボン組成物、それらの製剤及び放射線傷害に対する防護および処置用のその使用
Document Type and Number:
Japanese Patent JP4995396
Kind Code:
B2
Abstract:
The present invention provides compositions and methods for the prophylactic and therapeutic treatment of animals, including humans from radiation injury. In particular, the present invention provides methods and compositions comprising the isoflavone genistein (4′,5,7-trihydroxyflavone) or phytoestrogenic isoflavonoids.
Inventors:
Landauer, Michael Earl.
Seed, Thomas Michael
Sriniva San, Ben Kataraman
Shapiro, ara
Takimoto, Chris H.
Seed, Thomas Michael
Sriniva San, Ben Kataraman
Shapiro, ara
Takimoto, Chris H.
Application Number:
JP2002510114A
Publication Date:
August 08, 2012
Filing Date:
June 12, 2001
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Incorporated
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Incorporated
International Classes:
A23L1/30; A61K31/352; A23L11/00; A61K36/00; A61K36/48; A61K41/00; A61K47/34; A61N5/10; A61P3/06; A61P9/08; A61P9/14; A61P35/00; A61P39/00; A61P39/06; A61P43/00; C07D311/36
Domestic Patent References:
| JP11292898A |
Foreign References:
| WO1997046208A1 | ||||
| WO1998008503A1 | ||||
| WO2000004878A1 |
Other References:
H Kim et al.,Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor β signaling pathways,The American Journal of Clinical Nutrition,1998年,Vol.68(suppl),pp.1418S-1425S
AGARWAL,O.P. et al,Radioprotective property of flavonoids in mice.,Toxicon,1981年,Vol.19, No.2,pp.201-204
EMERIT,I. et al,Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements,Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis,1997年,Vol.377, No.2,pp.239-246
Radioprotective effects of antioxidative plant flavonoids in mice,Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis,1996年,Vol.350, No.1,pp.153-161
SHIMOI,K. et al,Radioprotective effect of antioxidative flavonoids in γ-ray irradiated mice,Carcinogenesis,1994年,Vol.15, No.11,pp.2669-2672
KEMERTELIDZE,E.P. et al,Structure-function analysis of the radioprotective and antioxidant activity of flavonoids,Chemistry of Natural Compounds(Translation of Khimiya Prirodnykh Soedinenii),2000年 1月,Vol.36, No.1,pp.54-59
AGARWAL,O.P. et al,Radioprotective property of flavonoids in mice.,Toxicon,1981年,Vol.19, No.2,pp.201-204
EMERIT,I. et al,Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements,Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis,1997年,Vol.377, No.2,pp.239-246
Radioprotective effects of antioxidative plant flavonoids in mice,Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis,1996年,Vol.350, No.1,pp.153-161
SHIMOI,K. et al,Radioprotective effect of antioxidative flavonoids in γ-ray irradiated mice,Carcinogenesis,1994年,Vol.15, No.11,pp.2669-2672
KEMERTELIDZE,E.P. et al,Structure-function analysis of the radioprotective and antioxidant activity of flavonoids,Chemistry of Natural Compounds(Translation of Khimiya Prirodnykh Soedinenii),2000年 1月,Vol.36, No.1,pp.54-59
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Yoichi Watanabe
Masaya Nishiyama
Higuchi Souji
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima
Jun Tsuruta
Yoichi Watanabe
Masaya Nishiyama
Higuchi Souji
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima