To obtain an isoquinoline derivative which has an excellent selective phosphodiesterase V-inhibiting action, exhibits an excellent vasodilator action, an excellent pulmonary artery pressure-lowering action and the like on the basis of the action and is useful as a medicine for preventing and treating chronic heart failure, stenocardia, (pulmonary)hypertension and the like.
A compound of formula I [ring A is a substituted benzene ring; ring B is a (substituted) benzene ring; R1 is a (substituted) lower alkoxy, a (substituted) cyclo lower alkyloxy, a (substituted) alkenyloxy or the like; R2 is COOR3 (R3 is H or an ester residue) or CON(R4)(R5) [N(R4)(R5) is a (substituted)nitrogen-containing heterocyclic group or (substituted) amino]], for example, 7-benzyloxy-1-chloro-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl) isoquinoline. The compound of formula I is produced, for example, by a method comprising halogenating an isoquinoline derivative (salt) of formula II to obtain a compound of formula III (R11 is a halogen).
| WO/2000/009480 | NOVEL SULFONYL DERIVATIVES |
| WO/2003/029221 | TETRAHYDROISOCHINOLINES, THEIR PRODUCTION AND THE USE THEREOF AS ANALGESICS |
| JP4686001 | Method for producing cyanoisoquinolines |
YAMADA KOICHIRO
OMORI KENJI
YOSHIKAWA KOHEI
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