ISOQUINOLINE INHIBITOR OF P38

Japanese Patent JP2009275054

A

To provide novel and strong inhibitors of p38 useful for treating various states associated with activation of p38.

The inhibitors of p38 are provided which is a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. Methods for producing the inhibitors are also provided. Pharmaceutical compositions comprises the inhibitors, and methods is for utilizing the compositions in treating and preventing various disorders.

JPH02215769	NITROGEN-CONTAINING CYCLIC COMPOUNDS SUCH AS 1-(2-ARYLETHYL)-PYRROLIDINE
JP6906437	Viral replication inhibitor
WO/2005/016876	CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT

COCHRAN JOHN E
ROGER D TAN

JP2009193707A

November 26, 2009

August 24, 2009

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VERTEX PHARMACEUT INC

C07D217/18; A61K31/472; A61K31/4725; A61K31/496; A61K31/551; A61K31/661; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/00; A61P7/00; A61P7/02; A61P7/04; A61P7/06; A61P7/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D217/22; C07D217/24; C07D401/04

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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