Title:
硫化剤およびオリゴヌクレオチドを合成するためのその使用
Document Type and Number:
Japanese Patent JP2012513450
Kind Code:
A
Abstract:
An oligonucleotide which comprises at least one internucleotide linkage comprising a P-S-R bond and at least two nucleosides, wherein R corresponds to the formula (I) wherein A is a geminally substituted alkylene group, preferably CH2, X and Y are independently selected from S and O, and R0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof.
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Inventors:
Muzzle Weeslaw Adam
Hi Eagan
Sorokin Victor
Hi Eagan
Sorokin Victor
Application Number:
JP2011542834A
Publication Date:
June 14, 2012
Filing Date:
December 23, 2009
Export Citation:
Assignee:
GIRINDUS AMERICA INC.
International Classes:
C07H21/04; C07C313/36; C07D207/48; C07H21/02; C12N15/09
Domestic Patent References:
| JPH10505094A | 1998-05-19 |
Foreign References:
| WO1998008809A1 | 1998-03-05 | |||
| WO1998049181A1 | 1998-11-05 | |||
| WO1998007734A1 | 1998-02-26 | |||
| US5770713A | 1998-06-23 |
Other References:
JPN6014010343; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ ７（３）, 1997, ｐ．２６３-２６８
JPN6014010344; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ ４（２０）, 1994, ｐ．２４７１-２４７６
JPN6014010345; Ｂｉｏｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ２３（１）, 1995, ｐ．１-２１
JPN6014010344; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ ４（２０）, 1994, ｐ．２４７１-２４７６
JPN6014010345; Ｂｉｏｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ２３（１）, 1995, ｐ．１-２１
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Yuko Otsuka
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Yuko Otsuka