Joint polypeptide which can be activated, an identification method for the same, and use - The Regents of The University of California

Title:

Joint polypeptide which can be activated, an identification method for the same, and use

Document Type and Number:

Japanese Patent JP6035009

Kind Code:

B2

Abstract:

The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an "activatable" conformation such that at least one of the TMBs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.

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Inventors:

Dougerty, patrick, scene
Stagliano, Nancy, E.
Thomas, Jerry
Kamas, Kathryn
West, James, W
Calle, Sanjay
Saggart, jason

Application Number:

JP2010521883A

Publication Date:

November 30, 2016

Filing Date:

August 21, 2008

Export Citation:

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Assignee:

The Regents of The University of California

International Classes:

C12N15/09; A61K38/00; A61K45/00; A61K47/42; A61K47/48; A61P35/00; A61P43/00; C07K14/00; C07K14/47; C07K14/515; C07K16/24; C07K16/28; C12N1/19; C12N1/20; C12N1/21; C12N5/10; C12N9/50; C12P21/02; C12Q1/37; G01N33/58; G01N33/68

Domestic Patent References:

JP2006506333A
JP2003534387A
JP2006503545A
JP2001511111A

Foreign References:

WO2004027045A2

Other References:

Mol.Pharm.,2004,Vol.1,No.1,p.9-22
Cell Death Differ.,Apr.2007,Vol.14,p.765-774

Attorney, Agent or Firm:

Naoto Uchida

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