ケタミンパモエート及びその使用

Japanese Patent JP7451538

B2

Provided are pamoate salts of ketamine having a stoichiometry of 2:1 of ketamine to pamoate, including R, S-ketamine pamoate, S-ketamine pamoate, or R-ketamine pamoate, and crystalline or amorphous forms of the pamoate salts, and having excellent safety and properties for pharmaceutical applications. Also provided are pharmaceutical compositions including the pamoate salts of ketamine and their uses in treating a CNS disease or serving as an anesthetic.

Tokazu Hayashi
Bun'ei Jun
Chen Jia-nen

JP2021540341A

March 18, 2024

January 10, 2020

Click for automatic bibliography generation  

Alar Pharmaceuticals Inc.

C07C225/20; A61K31/14; A61K31/192; A61P11/06; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P25/36; A61P27/16; C07C65/11

JP2014196292A
JP2011524409A
JP2003519698A

WO2018122626A1
WO2013035892A1
WO2017167180A1

川口洋子ら,医薬品と結晶多形,生活工学研究,2002年,Vol.4, No.2,p.310-317
"新医薬品の規格及び試験方法の設定について",医薬審発第568号,2001年05月01日
PHARM STAGE,2007年
高田則幸,創薬段階における原薬Formスクリーニングと選択,PHARM STAGE,Vol.6, No.10,2007年01月15日,p.20-25
山野光久,医薬品のプロセス研究における結晶多形現象への取り組み,有機合成化学協会誌,2007年,65(9),p.907-913
BYRN S,PHARMACEUTICAL SOLIDS: A STRATEGIC APPROACH TO REGULATORY CONSIDERATIONS,PHARMACEUTICAL RESEARCH,米国,KLUWER ACADEMIC PUBLISHERS,1995年07月01日

Norito Yamao
Yasushi Ochiai

Previous Patent: Various ecological compressed flush portable toilets

Next Patent: thermoelectric conversion element