Title:
ケトニトリル誘導体及びこれを含有する抗菌剤及び医薬
Document Type and Number:
Japanese Patent JP3670292
Kind Code:
B2
Abstract:
The present invention is directed to a ketonitrile derivative represented by the following formula (1): (wherein R<1> is a hydrogen atom or a lower alkyl group; each of R<2>, R<3>, R<4>, and R<5>, which may be identical to or different from each other, is a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, a lower alkoxyl group, or a substituted or unsubstituted phenoxy group; X is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; Y is a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted heterocyclic group, a carbonyl group that has been substituted by a substituted or unsubstituted aromatic hydrocarbon group, a carbonyl group that has been substituted by a substituted or unsubstituted heterocyclic group, an N,N-di-substituted carbamoyl group, or an alkyl group that has been substituted by a heterocyclic group) or a salt thereof, and to an antibacterial agent as well as to a drug containing, as the effective ingredient, the ketonitrile derivative or the salt. This compound exhibits excellent antibacterial activity against gram-positive bacteria and gram-negative bacteria.
Inventors:
Shozo Kato
Itanobu Hidenobu
Yamaguchi Masao
Makiko Furuki
Saint Nagata
Toshio Kitajima
Itanobu Hidenobu
Yamaguchi Masao
Makiko Furuki
Saint Nagata
Toshio Kitajima
Application Number:
JP50402397A
Publication Date:
July 13, 2005
Filing Date:
December 28, 1995
Export Citation:
Assignee:
Tokuyama Corporation
Daiichi Pharmaceutical Co., Ltd.
Daiichi Pharmaceutical Co., Ltd.
International Classes:
C07C255/21; C07C255/40; C07C259/06; C07D213/57; C07D213/643; C07D263/58; C07D295/185; C07D307/20; C07D309/12; C07D333/32; C07D401/12; C07D405/12; C07D409/12; C07D417/12; C07D213/64; (IPC1-7): C07C255/40; A01N37/34; A01N37/42; A01N43/04; A01N43/36; A01N43/40; A01N43/60; A01N43/74; A01N43/84; A61K31/275; A61K31/34; A61K31/35; A61K31/38; A61K31/445; A61P31/04; C07C255/41; C07C255/54; C07D211/16; C07D213/46; C07D241/44; C07D263/58; C07D277/68; C07D295/18; C07D307/16; C07D307/58; C07D309/12; C07D333/32; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12
Domestic Patent References:
| JP5148213A | ||||
| JP7109249A | ||||
| JP6179646A | ||||
| JP8333251A |
Attorney, Agent or Firm:
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba
Toshio Takano
Toshio Nakajima
Hiromi Matoba