Title:
ケトレダクターゼ突然変異体及びキラルアルコールの生産方法
Document Type and Number:
Japanese Patent JP7375052
Kind Code:
B2
Abstract:
Provided are a ketoreductase mutant and a method for producing chiral alcohol using the ketoreductase mutant. The ketoreductase mutant has a sequence with amino acid mutations in the sequence shown in SEQ ID NO:1. The mutation sites comprise at least one of the following positions: 6th position, 21st position, 42nd position, 58th position, 61st position, 76th position, 87th position, 94th position, 96th position, 108th position, 113th position, 117th position, 144th position, 146th position, 147th position, 149th position, 151st position, 152nd, 156th position, 165th position, 177th position, and 198th position.
Inventors:
Hong, Hao
James, Gauge
Xiao, Yi
Jean, Na
Jao, Shwechen
Jean, Cousien
Yang, Yimin
James, Gauge
Xiao, Yi
Jean, Na
Jao, Shwechen
Jean, Cousien
Yang, Yimin
Application Number:
JP2021573488A
Publication Date:
November 07, 2023
Filing Date:
June 13, 2019
Export Citation:
Assignee:
ASYMCHEM LABORATORIES (TIANJIN) CO., LTD.
International Classes:
C12N15/53; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12N15/70; C12N15/79; C12P7/02
Domestic Patent References:
| JP2007502124A | ||||
| JP2010252657A |
Foreign References:
| CN108048417A | ||||
| CN109468293A | ||||
| CN109355265A | ||||
| WO2018200214A2 |
Attorney, Agent or Firm:
Patent Attorney Tsutsui International Patent Office