Title:
糖尿病及び肥満の治療のためのキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2008518932
Kind Code:
A
Abstract:
The present invention discloses a method of treating an individual or animal with diabetes and/or obesity. The method comprises administering to the individual or animal a therapeutically effective amount of a protein tyrosine kinase inhibitor. Preferably, the preventative and therapeutic methods of the present invention involve administering-to a mammal in need thereof-a therapeutically effective amount of an inhibitor of a c-Src-family protein tyrosine kinase. The invention pertains to pharmaceutical compositions containing an inhibitor of a c-Src-family protein tyrosine kinase or an analog or metabolite thereof, or an inhibitor of another protein tyrosine kinase, and a pharmaceutically acceptable carrier. Purines and pyrimidines and other molecules useful in the treatment of diabetes and obesity are provided herein, in particular, pyrazolopyrimidines, cyanoquinolines, phenylaminopyrimidines, anilinoquinazolines and related compounds. The invention also provides cellular targets and assay compositions useful for the identification of additional novel therapeutic agents for the treatment of these disorders.
Inventors:
Westwick John Kay
Lamardin Jane
Owens Stephen
McDonald Marnie El
Lamardin Jane
Owens Stephen
McDonald Marnie El
Application Number:
JP2007539192A
Publication Date:
June 05, 2008
Filing Date:
October 29, 2005
Export Citation:
Assignee:
Odyssey Sera Inc.
International Classes:
A61K45/00; A61K31/7105; A61K31/711; A61K48/00; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P7/02; A61P9/10; A61P9/12; A61P25/00; A61P27/02; A61P29/00; A61P43/00; G01N33/15; G01N33/50
Foreign References:
| US20030208067A1 | 2003-11-06 | |||
| US20040171563A1 | 2004-09-02 | |||
| US20030232391A1 | 2003-12-18 |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes