Title:
ラセミ体δ−ヒドロキシエステルの触媒的不斉水素化反応による動力学的分割およびその応用
Document Type and Number:
Japanese Patent JP6487568
Kind Code:
B2
Abstract:
The present invention relates to kinetic resolution of racemic ´ -hydroxyl ester via asymmetric catalytic hydrogenation and an application thereof. In the presence of chiral spiro pyridyl phosphine ligand Iridium catalyst and base, racemic ´-hydroxyl esters were subjected to asymmetric catalytic hydrogenation to obtain extent optical purity chiral ´-hydroxyl esters and corresponding 1,5-diols. The method is a new, efficient, highly selective, economical, desirably operable and environmentally friendly method suitable for industrial production. An optically active chiral ´ -hydroxyl ester and 1,5-diols can be obtained at very high enantioselectivity and yield with relatively low usage of catalyst. The chiral ´ -hydroxyl ester and 1,5-diols obtained by using the method can be used as a critical raw material for asymmetric synthesis of chiral drugs (R)-lisofylline and natural drugs (+)-civet, (-)-indolizidine 167B and (-)-coniine.
Inventors:
Zhou Chirin
Sieghenhua
Yan Xiaohui
Warn Lee Shin
Sieghenhua
Yan Xiaohui
Warn Lee Shin
Application Number:
JP2017547036A
Publication Date:
March 20, 2019
Filing Date:
August 08, 2015
Export Citation:
Assignee:
Jezian Jiuzhou Pharmaceutical Company, Limited
International Classes:
C07C67/60; C07C29/149; C07C31/20; C07C33/26; C07C41/26; C07C43/13; C07C69/675; C07C69/708; C07C69/732; C07D211/12; C07D309/06; C07D471/04; C07D473/10
Domestic Patent References:
| JP2014501719A | ||||
| JP2013056848A | ||||
| JP2011037809A |
Foreign References:
| WO2007026875A1 |
Other References:
J. Am. Chem. Soc.,2014年12月 1日,136,17426-17429
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima
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