Title:
キノリジノンM1受容体ポジティブアロステリックモジュレーター
Document Type and Number:
Japanese Patent JP2011500678
Kind Code:
A
Abstract:
The present invention is directed to spiropiperidine compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Inventors:
Kudatsuk, Scott Day
Ryanald Kaye, Jiang
Ryanald Kaye, Jiang
Application Number:
JP2010529934A
Publication Date:
January 06, 2011
Filing Date:
October 15, 2008
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D455/02; A61K31/4375; A61K31/498; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/02; A61P21/00; A61P25/00; A61P25/04; A61P25/16; A61P25/18; A61P25/20; A61P25/28; A61P27/06; A61P43/00
Attorney, Agent or Firm:
Kawaguchi International Patent Office