Title:
Ｌ－２－ヒドロキシグルタル酸及びストレス誘発性代謝
Document Type and Number:
Japanese Patent JP7208323
Kind Code:
B2
Abstract:
The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
Inventors:
Andrew M. In Turkey Far
Craig Bee. Thompson
Craig Bee. Thompson
Application Number:
JP2021159462A
Publication Date:
January 18, 2023
Filing Date:
September 29, 2021
Export Citation:
Assignee:
Memorial Sloan Kettering Cancer Center
International Classes:
G01N33/68; A61K31/194; A61K31/198; A61K31/225; A61K45/00; A61K49/00; A61P7/02; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P29/00; A61P31/04; A61P35/00; A61P37/06; A61P41/00; A61P43/00; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| JP2013506833A |
Foreign References:
| WO2013075065A1 | ||||
| WO2013086365A2 |
Other References:
Rakheja, D. et al.,Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate,Tumor Biology,Springer,2010年11月16日,Vol.32,pp.325-333
STRUYS, E.A. et al.,Measurement of Urinary D- and L-2-Hydroxyglutarate Enantiomers by Stable-Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry after Derivatization with Diacetyl-L-Tartaric Anhydride,Clinical Chemistry,2004年08月01日,Vol.50/No.8,pp.1391-1395
STRUYS, E.A. et al.,Measurement of Urinary D- and L-2-Hydroxyglutarate Enantiomers by Stable-Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry after Derivatization with Diacetyl-L-Tartaric Anhydride,Clinical Chemistry,2004年08月01日,Vol.50/No.8,pp.1391-1395
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki
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