Title:
Ｔ細胞受容体α遺伝子を開裂するＬＡＧＬＩＤＡＤＧホーミングエンドヌクレアーゼおよびその用途
Document Type and Number:
Japanese Patent JP6450371
Kind Code:
B2
Abstract:
Disclosed herein are compositions for inactivating the human TCR-alpha gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHEs. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefore are also provided.
Inventors:
Astrakhan alexander
Jersey jordan
Jersey jordan
Application Number:
JP2016516173A
Publication Date:
January 09, 2019
Filing Date:
May 28, 2014
Export Citation:
Assignee:
CELLECTIS
International Classes:
C12N15/09; A61K35/12; A61K35/15; A61K35/17; A61K35/28; A61K48/00; A61P35/00; C07K19/00; C12N9/16; C12N15/90
Foreign References:
| WO2011156430A2 | ||||
| WO2013009525A1 | ||||
| WO2012138927A2 | ||||
| WO2013068845A2 |
Other References:
Blood,2012年 6月14日,Vol.119, No.24,p.5697-5705
PROVASI Elena, et al.,TCR Gene Editing Results in Effective Immunotherapy of Leukemia without the Development of GvHD,Blood,2011年,Vol.118, No.21,p.667
Proceedings of The National Academy of Sciences,2011年 8月 1日,Vol.108, No.32,p.13077-13082
Nucleic Acids Research,2012年 6月 7日,Vol.40, No.16,p.7985-8000
Nucleic Acids Research,2011年 8月 3日,Vol.39, No.21,p.9283-9293
Genome,2012年 8月,Vol.55, No.8,p.553-569
Methods Mol Biol,2013年 1月12日,Vol.978,p.45-61
PROVASI Elena, et al.,TCR Gene Editing Results in Effective Immunotherapy of Leukemia without the Development of GvHD,Blood,2011年,Vol.118, No.21,p.667
Proceedings of The National Academy of Sciences,2011年 8月 1日,Vol.108, No.32,p.13077-13082
Nucleic Acids Research,2012年 6月 7日,Vol.40, No.16,p.7985-8000
Nucleic Acids Research,2011年 8月 3日,Vol.39, No.21,p.9283-9293
Genome,2012年 8月,Vol.55, No.8,p.553-569
Methods Mol Biol,2013年 1月12日,Vol.978,p.45-61
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto