Title:
トリアシルグリセロールリパーゼファミリーのLLGポリペプチド、組成物、酵素的加水分解における使用のための方法、タンパク質及び遺伝子治療
Document Type and Number:
Japanese Patent JP4615634
Kind Code:
B2
Abstract:
Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
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Inventors:
Jay michael sea
Doan Kim Ante
Cla Week John A
Lynch Kevin Jay
Amin Dillie Ve
South Victoria Jay
Doan Kim Ante
Cla Week John A
Lynch Kevin Jay
Amin Dillie Ve
South Victoria Jay
Application Number:
JP52582298A
Publication Date:
January 19, 2011
Filing Date:
December 05, 1997
Export Citation:
Assignee:
Aventis Pharmaceuticals Incorporated
International Classes:
A01K67/027; A61K38/00; C12N15/09; A61K38/46; A61K39/395; A61K45/00; A61K48/00; A61P3/06; C07K16/40; C12N5/10; C12N9/00; C12N9/16; C12N9/18; C12N9/20; C12P9/00; C12P21/08; C12Q1/44; G01N33/15; G01N33/50; C12R1/91
Other References:
AMEIS,D. et al, Isolation and characterization of the human hepatic lipase gene, J. Biol. Chem., 1990年, Vol.265, No.12, pp.6552-6555
HIDE,W.A. et al, Structure and evolution of the lipase superfamily, J. Lipid Res., 1992年, Vol.33, No.2, pp.167-178
VAN,T.O, et al, Degradation of high density lipoprotein by heparin-releasable liver lipase, Biochem. Biophys. Res. Commun., 1980年, Vol.94, No.1, pp.101-108
EHNHOLM,C. et al, Purification from human plasma of a heparin-released lipase with activity against triglyceride and phospholipids, J. Biol. Chem., 1975年, Vol.250, No.17, pp.6756-6761
VAN,T.I. et al, Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysis, J. Biol. Chem., 1994年, Vol.269, No.6, pp.4626-4633
COOPER,D.A. et al, The structure and complete nucleotide sequence of the avian lipoprotein lipase gene, Biochim. Biophys. Acta., 1992年, Vol.1129, No.2, pp.166-171
DUGI,K.A. et al, Human hepatic and lipoprotein lipase: the loop covering the catalytic site mediates lipase substrate specificity, J. Biol. Chem., 1995年, Vol.270, No.43, pp.25396-25401
HIDE,W.A. et al, Structure and evolution of the lipase superfamily, J. Lipid Res., 1992年, Vol.33, No.2, pp.167-178
VAN,T.O, et al, Degradation of high density lipoprotein by heparin-releasable liver lipase, Biochem. Biophys. Res. Commun., 1980年, Vol.94, No.1, pp.101-108
EHNHOLM,C. et al, Purification from human plasma of a heparin-released lipase with activity against triglyceride and phospholipids, J. Biol. Chem., 1975年, Vol.250, No.17, pp.6756-6761
VAN,T.I. et al, Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysis, J. Biol. Chem., 1994年, Vol.269, No.6, pp.4626-4633
COOPER,D.A. et al, The structure and complete nucleotide sequence of the avian lipoprotein lipase gene, Biochim. Biophys. Acta., 1992年, Vol.1129, No.2, pp.166-171
DUGI,K.A. et al, Human hepatic and lipoprotein lipase: the loop covering the catalytic site mediates lipase substrate specificity, J. Biol. Chem., 1995年, Vol.270, No.43, pp.25396-25401
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Nobuo Ogawa
Fumiaki Otsuka
Nobuo Ogawa