Title:
生体分子相互作用の検出のためのラベル化不用ハイスループット光学技術
Document Type and Number:
Japanese Patent JP4202140
Kind Code:
B2
Abstract:
An instrument system for detecting biochemical interactions on a biosensor, said instrument system comprising:
(a) a biosensor comprising:
(i) a two-dimensional grating;
(ii) a substrate that supports the two-dimensional grating; wherein the refractive index of the two-dimensional grating is greater than the refractive index of the substrate; and
(iii) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate; wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected or transmitted radiation spectrum of incident light by generation of a leaky mode in the grating; and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect;
(b) a light source;
(c) a first optical fiber coupled to the light source, wherein the first optical fiber illuminates the biosensor;
(d) a second optical fiber that detects a signal reflected or transmitted from the surface of the biosensor; and
(e) a spectrometer for determining spectra of the reflected or transmitted signal from the biosensor.
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Inventors:
Cunningham, Bryan, Tea
Jane, Pepper
Lynn, Bo
Lee, Peter
Homer, Pien
Jane, Pepper
Lynn, Bo
Lee, Peter
Homer, Pien
Application Number:
JP2002561944A
Publication Date:
December 24, 2008
Filing Date:
October 23, 2001
Export Citation:
Assignee:
S.R.U.Biosystems, Inc.
International Classes:
G01N33/543; B01L3/00; G01N21/25; G01N21/27; G01N21/35; G01N21/47; G01N33/566; G02B5/18
Domestic Patent References:
| JP8504955A | ||||
| JP6455502A | ||||
| JP650972A | ||||
| JP2001516020A | ||||
| JP5506937A |
Attorney, Agent or Firm:
Seiji Ohno
Koji Morita
Reiko Tanaka
Ken Kitano
Koji Morita
Reiko Tanaka
Ken Kitano