Title:
免疫調節性機能を誘導する乳酸菌類とその成分
Document Type and Number:
Japanese Patent JP4589618
Kind Code:
B2
Abstract:
To provide a method of obtaining and of effectively selecting a microorganism that contributes to prevention and treatment of immune diseases including allergy, autoimmune diseases and inflammatory bowel diseases (e.g., large-intestinal ulcer), and a method of efficiently inducing immunoregulatory cells that play an important role on maintaining immunological homeostasis using the microorganism or the ingredient thereof. The present invention provides a method of obtaining or of selecting a microorganism or its cellular components, which is selected from a Lactococcus and an ingredient thereof, which induce production of IL-10 from mammalian dendritic or spleen cells. The invention comprises a method of obtaining the microorganism or the ingredient thereof by co-culturing a microorganism such as Lactococcus strains with mammalian dendritic or spleen cells to select a microbial cell having a high IL-10 production ability, a method of selecting the microorganism or the ingredient thereof by co-culturing an intestinal epithelial cell with a microorganism such as the lactic acid bacteria and selecting the cells on the basis of a caspase-1 activity and the ability of inducing the production of IL-18, and a method for obtaining a food product or material and an animal feeding stuff or medical and pharmaceutical products which contain the lactic acid bacteria as an effective ingredient.
Inventors:
Noriko Tsuji
Hiromi Kimoto
Hiromi Kimoto
Application Number:
JP2003398662A
Publication Date:
December 01, 2010
Filing Date:
November 28, 2003
Export Citation:
Assignee:
NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES
Centro Internacional de Agricultura Tropical
Centro Internacional de Agricultura Tropical
International Classes:
A61K35/74; A23C9/00; A23C19/00; A23C19/032; A23L29/00; A23L33/135; A61K35/744; A61P1/04; A61P37/02; A61P37/08; C12N1/20; C12P21/02; C12Q1/00; C12Q1/02
Domestic Patent References:
| JP7099986A | ||||
| JP2000256201A | ||||
| JP5065229A |
Other References:
MIETTINEN M ET AL,Production of human tumor necrosis factor alpha, interleukin-6, and interleukin - 10 is induced by lactic acid bacteria,INFECTION AND IMMUNITY,1996年,64(12),pp.5403-5405
VON DER WEID T ET AL,Induction by a lactic acid bacterium of a population of CD4<+> T cells with low proliferative capacity that produce transforming growth factor [beta] and interleukin-10,CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY 2001 UNITED STATES ,2001年,vol.8,no.4,pages 695-701
RIGBY RACHAEL J ET AL,Differential production of IL-12 and IL-10 by colonic dendritic cells (DC) in response to bacterial stimuli,GASTROENTEROLOGY,2002年,vol.122,no.4,Suppl.1
VON DER WEID T ET AL,Induction by a lactic acid bacterium of a population of CD4<+> T cells with low proliferative capacity that produce transforming growth factor [beta] and interleukin-10,CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY 2001 UNITED STATES ,2001年,vol.8,no.4,pages 695-701
RIGBY RACHAEL J ET AL,Differential production of IL-12 and IL-10 by colonic dendritic cells (DC) in response to bacterial stimuli,GASTROENTEROLOGY,2002年,vol.122,no.4,Suppl.1
Attorney, Agent or Firm:
Yuya Yano