Title:
擬似三糖アミノグリコシドおよびその中間体の大規模調製
Document Type and Number:
Japanese Patent JP7187471
Kind Code:
B2
Abstract:
Synthetic pathways for preparing pseudo-trisaccharide aminoglycoside compounds represented by Formula I or Ia as defined in the specification and donor and acceptor compounds useful for preparing such compounds are provided. A process of stereoselectively preparing compounds represented by Formula III as defined in the specification, while avoiding chromatographic separation of stereoisomers are also provided. Compounds prepared by the described processes and uses thereof are also provided.
Inventors:
Mizuhiritsusky, Michael
Kotara, Mani Bushan
Paradis, Ravindel
Kotara, Mani Bushan
Paradis, Ravindel
Application Number:
JP2019551278A
Publication Date:
December 12, 2022
Filing Date:
March 15, 2018
Export Citation:
Assignee:
Erox Pharmaceuticals Limited
International Classes:
C07H13/12; C07H9/04; C07H15/23
Domestic Patent References:
| JP2013542981A |
Other References:
DONDONI,A. et al,Stereoselective Addition of 2-Furyllithium and 2-Thiazolyllithium to Sugar Nitrones. Synthesis of Carbon-Linked Glycoglycines,Journal of Organic Chemistry,1997年,Vol.62, No.16,p.5484-5496
BRIMACOMBE,J.S. et al,The deamination of methyl 5-amino-5,6-dideoxy-2,3-O-isopropylidene-α-L- talo- and -β-D-allo-furanosides with nitrous acid,Carbohydrate Research,1972年,Vol.25, No.1,p.267-269
BRIMACOMBE,J.S. et al,The deamination of methyl 5-amino-5,6-dideoxy-2,3-O-isopropylidene-α-L- talo- and -β-D-allo-furanosides with nitrous acid,Carbohydrate Research,1972年,Vol.25, No.1,p.267-269
Attorney, Agent or Firm:
Masatoshi Kurata
Nobuhisa Nogawa
Tadashi Inoue
Shigeru Iino
Naoki Kono
Sanae Kaneko
Nobuhisa Nogawa
Tadashi Inoue
Shigeru Iino
Naoki Kono
Sanae Kaneko