PURPOSE: To obtain a reagent having excellent preservable stability by forming a latex reagent constituted by sensitizing an immune material to latex particles in such a manner said reagent has the average particle size of a prescribed range and that the ratio between the average particle size thereof and the average particle size of the latex particles attain the value of a specified range.
CONSTITUTION: The average particle size of the latex particles to be used is not particularly limited and the latex particles having the average particle size ranging 0.05W0.38, more preferably 0.07W0.3μ are particularly adequate; further, the reproducibility is better with the particles having the smaller dispersion value of the particle sizes. The latex reagent is obtd. by sensitizing the immune active material with the latex particles. This reagent is required to have the average particle size D ranging; for example, 0.1W0.5μm. The ratio D/d of the average D of the particle of the reagent to the average particle size (d) of the latex particles is required to be in; for example, 1.3W3.0 range. The reagent has the high preservable stability but hardly detects the antigen of a low concn. if D/d is <1.3. Large agglutinated particles are generated at the time of sensitization and the agglutination arises non-specifically at the time of preservation when D/d exceeds 3.0.
| JPS61155958 | IMMUNOLOGICAL DIAGNOSTIC REAGENT |
| WO/2000/046601 | DETECTING TELOMERASE ACTIVITY |
| WO/1995/024437 | POLYMER-CONJUGATED MALONIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS AND DIAGNOSTIC AGENTS |
MITANI KATSUO
EDA YOSHITO
