Title:
LEUKOTRIENE ANTAGONISTIC SUBSTANCE
Document Type and Number:
Japanese Patent JPS6045541
Kind Code:
A
Abstract:
Compounds of the forrnula I: and their pharmaceutically acceptable salts are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders. For this purpose they are made into pharmaceutical composition. In the formula, A/ &cir& and B are hydrogen or certain rings, X is O, S, SO, or SO2; Y is H, OH, O, or OR<2>; n is 0, 1 or 2; a, b and c are 0 to 5; R<1> is one of CH2OH, CHO, tetrazolyl, CN, certain phenolic heterocycles, certain esterfied carboxyls, hydroxymethyl ketone, and certain substituted carbamoyl and sulfonylamino groups; and R<2> and R<3> are H or alkyl or form a ring.
Inventors:
ROBAATO ENU YANGU
HEIDON DABURIYU AARU UIRIAMUSU
JIYOSHIYUA ROKATSUCHI
MASATOSHI KAKUSHIMA
IBUAN GIYUINDON
HEIDON DABURIYU AARU UIRIAMUSU
JIYOSHIYUA ROKATSUCHI
MASATOSHI KAKUSHIMA
IBUAN GIYUINDON
Application Number:
JP7877984A
Publication Date:
March 12, 1985
Filing Date:
April 20, 1984
Export Citation:
Assignee:
MERCK FROSST CANADA INC
International Classes:
A61K31/045; A61K31/075; A61K31/095; A61K31/11; A61K31/12; A61K31/16; A61K31/215; A61K31/275; A61K31/35; A61K31/351; A61K31/352; A61K31/38; A61K31/381; A61K31/47; A61P9/08; A61P9/10; A61P11/00; A61P17/00; A61P27/16; A61P37/08; C07C27/00; C07C45/00; C07C47/26; C07C67/00; C07C69/66; C07C205/38; C07C213/00; C07C217/76; C07C217/78; C07C227/00; C07C229/22; C07C231/00; C07C233/66; C07C233/78; C07C235/04; C07C235/28; C07C235/34; C07C235/38; C07C253/00; C07C255/02; C07C255/06; C07C301/00; C07C303/22; C07C303/40; C07C311/00; C07C313/00; C07C313/28; C07C317/00; C07C317/18; C07C317/24; C07C317/28; C07C317/44; C07C317/46; C07C323/22; C07C323/41; C07C323/56; C07C323/61; C07C323/62; C07C323/63; C07D215/54; C07D303/40; C07D307/85; C07D309/30; C07D309/36; C07D309/40; C07D311/14; C07D311/16; C07D311/18; C07D311/22; C07D311/24; C07D333/08; C07D333/24; C07D333/38; C07D405/14; C07D409/12; C07F7/18; C07K5/06; A61K38/00; (IPC1-7): A61K31/045; A61K31/075; A61K31/095; A61K31/11; A61K31/12; A61K31/16; A61K31/215; A61K31/275; A61K31/35; A61K31/38; A61K31/47; C07/; C07C31/20; C07C33/02; C07C33/04; C07C33/26; C07C33/28; C07C33/36; C07C33/40; C07C39/11; C07C39/12; C07C39/18; C07C39/205; C07C39/23; C07C39/24; C07C43/178; C07C43/235; C07C47/19
Attorney, Agent or Firm:
Masao Okabe