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Title:
LIFE PROLONGATION-EFFECTIVE SUBSTANCE, AND INFECTION-PROTECTING EFFECT AND VACCINE EFFECT-PROMOTING SUBSTANCE, CONSTRUCT FOR ASSAYING THE ABOVE SUBSTANCES, AND APPLICATION OF THE ABOVE SUBSTANCES
Document Type and Number:
Japanese Patent JP2008195673
Kind Code:
A
Abstract:

To provide a substance having life prolongation effect and antiaging effect, a substance having infection-protecting effect and vaccine effect, and to provide a method for efficiently assaying these substances.

The life prolongation-effective substance characterized by enhancing Sirtuin gene activity, and the infection-protecting effect and vaccine effect-promoting substance characterized by enhancing AID (activation-induced cytidine deaminase) gene activity are provided, respectively. Foods, pharmaceuticals, cosmetics or reagents each containing either one of the above substances are also provided, respectively. Further, a construct for assaying the life prolongation-effective substance, characterized by having a polynucleotide having Sirtuin gene promoter activity, and a construct for assaying the infection-protecting effect and vaccine effect-promoting substance, characterized by having a polynucleotide having AID gene promoter activity, are provided, respectively. In addition, the method for assaying the respective substances using these constructs is provided.


Inventors:
KATAKURA YOSHINORI
SHIRAHATA SANETAKA
TERUYA TERUICHIRO
YAMASHITA MAKIKO
MATSUMOTO TAKAYUKI
HASEGAWA TAKANORI
Application Number:
JP2007034115A
Publication Date:
August 28, 2008
Filing Date:
February 14, 2007
Export Citation:
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Assignee:
NIPPON MEAT PACKERS
UNIV KYUSHU
International Classes:
A61K45/00; A23L1/30; A23L33/10; A23L33/135; A61K8/99; A61K35/74; A61K35/747; A61P31/00; A61P37/00; A61P39/00; A61P43/00; A61Q19/08; C12N5/10; C12N15/09; C12Q1/02; C12Q1/34; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50
Domestic Patent References:
JP2001258549A2001-09-25
JPH1084909A1998-04-07
JP2006291146A2006-10-26
JPS61109729A1986-05-28
JPS62145026A1987-06-29
JP2005225841A2005-08-25
JP2001270830A2001-10-02
JP2006273852A2006-10-12
JP2001346581A2001-12-18
Foreign References:
WO2006093313A12006-09-08
Other References:
JPN6012004951; 饗場浩文: '"赤ワインを飲んで長生きを！"' 化学と生物 Ｖｏｌ．４２，Ｎｏ．２, 20040225, Ｐ．１１４-１１５
JPN6012026338; 藤木司　外５名: '"飢餓応答としての延命の分子機構に関する解析"' 日本農芸化学会大会講演要旨集 Ｖｏｌ．２００６, 20060305, Ｐ．２８８
JPN6012061803; Ｈａｉｇｉｓ，Ｍ．Ｃ．　ｅｔ　ａｌ．: 'Ｍａｍｍａｌｉａｎ　ｓｉｒｔｕｉｎｓ　-　ｅｍｅｒｇｉｎｇ　ｒｏｌｅｓ　ｉｎ　ｐｈｙｓｉｏｌｏｇｙ，ａｇｉｎｇ，　ａｎｄ　ｃａｌｏｒｉｅ　ｒｅｓｔｒｉｃｔｉｏｎ' Ｇｅｎｅｓ　Ｄｅｖ． Ｖｏｌ．２０，Ｎｏ．２１, 20061101, Ｐ．２９１３-２９２１
JPN6012061804; 手島珠紀　外５名: '『Ｌａｃｔｏｂａｃｉｌｌｕｓ　ｇａｓｓｅｒｉ　ＳＢＴ２０５５株のプロバイオティクス機能の検証　-加齢に伴う生体機能変化と長期経口投' 日本農芸化学会大会講演要旨集 Ｖｏｌ．２００２, 20020305, Ｐ．１０６
JPN6012061805; 田中博　外５名: '『Ｂｉｆｉｄｏｂａｃｔｅｒｉｕｍ　ｌｏｎｇｕｍ　ＳＢＴ２９２８株のプロバイオティクス機能の検証（その２）加齢に伴う生体機能変化と長' 日本農芸化学会大会講演要旨集 Ｖｏｌ．２００２, 20020305, Ｐ．１０６
JPN6012061806; 鈴木豊　外３名: '『ヨーグルトおよびビフィズス発酵乳がマウスの生存率と血清成分値に及ぼす影響』' 日本栄養・食糧学会誌 Ｖｏｌ．４４，Ｎｏ．３, 1991, Ｐ．１７７-１８２
JPN6012061808; 荒井幸一郎　外４名: '報文　『殺菌発酵乳投与のマウスの寿命、腸内菌叢におよぼす影響について（予報）』' 栄養と食糧 Ｖｏｌ．３３，Ｎｏ．４, 1980, Ｐ．２１９-２２３
Attorney, Agent or Firm:
Hiroaki Sakai



 
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