Title:
核酸の送達のための脂質および脂質ナノ粒子製剤
Document Type and Number:
Japanese Patent JP7443296
Kind Code:
B2
Abstract:
Compounds are provided having the following structure:or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
Inventors:
Do, Shin Yao
Ansel, Stephen M.
Ansel, Stephen M.
Application Number:
JP2021110236A
Publication Date:
March 05, 2024
Filing Date:
July 01, 2021
Export Citation:
Assignee:
Aquitas Therapeutics Incorporated
International Classes:
C07C233/36; A61K9/127; A61K31/7088; A61K31/7105; A61K47/18; A61K47/24; A61K47/28; A61K48/00; C07C233/38; C07C235/74
Domestic Patent References:
| JP2013527856A | ||||
| JP2015501309A | ||||
| JP7072386B2 |
Attorney, Agent or Firm:
Norito Yamao
Sei Morimoto
Sei Morimoto
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