LIPID NANOPARTICLE COMPOSITIONS FOR ANTISENSE OLIGONUCLEOTIDE DELIVERY

Title:

LIPID NANOPARTICLE COMPOSITIONS FOR ANTISENSE OLIGONUCLEOTIDE DELIVERY

Document Type and Number:

Japanese Patent JP2018002727

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide lipid nanoparticle compositions that can encapsulate therapeutic oligonucleotides and fulfill physical and biological criteria for efficacious delivery.SOLUTION: A lipid nanoparticle composition includes a cationic liposome, a targeting agent, and a hyper-cationized albumin-polycation conjugate. The lipid nanoparticle encapsulates the hyper-cationized albumin-polycation conjugate for making a lipid-coated albumin nanoparticle (LCAN).SELECTED DRAWING: Figure 1

Inventors:

ROBERT J LEE
LEE YOUNG BOK
KIM DEOG JOONG
AHN CHANG HO

Application Number:

JP2017191221A

Publication Date:

January 11, 2018

Filing Date:

September 29, 2017

Export Citation:

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Assignee:

UNIV OHIO STATE

International Classes:

A61K9/16; A61K9/127; A61K31/519; A61K31/7088; A61K31/7105; A61K31/713; A61K31/715; A61K38/08; A61K38/16; A61K38/18; A61K38/40; A61K39/395; A61K47/14; A61K47/18; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61K47/42; A61K48/00; A61K51/08

Domestic Patent References:

JP2015519346A

2015-07-09

Other References:

CYTOKINE, vol. 29, JPN6016043514, 2005, pages 283 - 287, ISSN: 0003861950

Attorney, Agent or Firm:

Patent Business Corporation Tani/Abe Patent Office

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