Title:
脂質ナノ粒子製剤
Document Type and Number:
Japanese Patent JP7332478
Kind Code:
B2
Abstract:
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
Inventors:
Patel, Siddhartha
Robinson, Emily
Brown, Anna
Armerson, Orn
Benenato, Kelly E.
Subnis, Stacy
Sahei, Goraf
Narayana, Ashwani Kumar
Robinson, Emily
Brown, Anna
Armerson, Orn
Benenato, Kelly E.
Subnis, Stacy
Sahei, Goraf
Narayana, Ashwani Kumar
Application Number:
JP2019550770A
Publication Date:
August 23, 2023
Filing Date:
March 15, 2018
Export Citation:
Assignee:
ModernaTX,Inc.
OREGON STATE UNIVERSITY
OREGON STATE UNIVERSITY
International Classes:
A61K47/28; A01K67/027; A61K9/107; A61K31/404; A61K31/41; A61K31/47; A61K31/7105; A61K31/713; A61K47/18; A61K47/22; A61K47/24; A61K47/34; A61K48/00; A61P3/00; A61P3/10; A61P5/46; A61P9/00; A61P13/12; A61P31/00; A61P35/00; A61P37/06; A61P43/00; C12N5/10; C12N15/11; C12N15/113; C12N15/88; C12P21/02
Foreign References:
| WO2016118724A1 |
Other References:
大神 信孝,細胞内のタンパク質はコレステロールのどこを認識して輸送しているのか?,生命健康科学研究所紀要,日本,2008年,第4号,第35頁-第40頁
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Miki Nakamura
Hironobu Onda
Atsushi Honda
Miki Nakamura
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